South Kenton is situated on the southern fringe of Northwick Park in an area which was previously open farmland with virtually no settlement.

Its station opened on 3 July 1933 with access from both sides of the railway via a footbridge to the single island platform serving. The further growth of South Kenton was stimulated by the arrival of the railway.

South Kenton’s station footbridge was later replaced by a pedestrian tunnel, cutting out a long climb for passengers entering the station. The station was designed by the architect William Henry Hamlyn and built in concrete and glass.