Gwynne Road dates from the 1860s.
Between the Lombard estate and the railway embankment to its north lay a narrow strip of ground acquired for £7000 in 1864 by James E. A. Gwynne, a civil engineer born in Ireland (in 1833) and at the time living in St Marylebone.
Here, in 1868, George Todd laid out a road called Gwynne Road connecting Lombard Road and the High Street. Its route lined up with Simpson Street, on the other side of the High Street - Todd had laid Simpson Street out only a few years earlier.