Goldhawk Road’s name derives from one John Goldhawk, who in the late 14th century held extensive estates in Fulham.

Goldhawk Road was of little note until the mid-seventeenth century, when a cottage on the street became the home of one Miles Sindercombe, a disgruntled Roundhead who in 1657 made several attempts to assassinate Oliver Cromwell. Sindercombe planned to ambush the Lord Protector using a specially built machine with muskets fixed to a frame. His plan failed, Sindercombe was sentenced to death, and his cottage was eventually demolished in the 1760s.

A map of London dated 1841 shows Goldhawk Road forming the southern boundary of Shepherd’s Bush Green. At that time Shepherd’s Bush was still largely undeveloped and rural in character, with much open farmland compared to fast-developing Hammersmith, and several ponds or small lakes. Scattered buildings are shown, mostly lining the main thoroughfares of Wood Lane, Cumberland Road (now the Uxbridge Road), and Goldhawk Road.

From 1939 until 1999 Queen Charlotte’s Hospital was situated in Goldhawk Road.

In 1982 Alexei Sayle filmed the video for 'Ullo John! Gotta New Motor? in Goldhawk Road.