Powis Place was built on the former site of Powis House, built for William Herbert, 2nd Marquess of Powis, a prominent 17th/18th century Jacobite.
Powis Place extends northward from Great Ormond Street as a cul-de-sac in eastern Bloomsbury. Developed following the 1784 demolition of Powis House, the street occupies the former approach to the original mansion, built in the 1690s and reconstructed after a 1714 fire. The house, set back from Great Ormond Street, possessed gardens stretching to Powis Wells, a fashionable spa near present-day Guilford Street.
Powis Place, an upmarket development attracted notable residents, including merchant Antony Gibbs from 1812-1815, whose grandson, Henry Hucks Gibbs (later Baron Aldenham), was born at number 2 in 1819. Architect James Lewis resided here until his death in 1820, whilst number 10 housed legal author Henry Roscoe and family, including his son, pioneering chemist Sir Henry Enfield Roscoe, born there in 1833.
The street’s social character evolved, hosting Peter Alfred Taylor’s radical salon in the 1850s, caricaturist John Leech at number 6, and later the Female Aid Society’s Home for Friendless Girls. By 1879, the residents included craftsmen like gun case maker Lauret Holmes and currier Walter Worsdell. Though converted into flats, the buildings retained their residential nature whilst existing in the shadow of the neighbouring Homeopathic and Children’s hospitals.
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