The name "Soho" first appears in the 17th century. Most authorities believe that the name derives from a former hunting cry. James Scott, 1st Duke of Monmouth, used "soho" as a rallying call for his men at the Battle of Sedgemoor on 6 July 1685, half a century after the name was first used for this area of London. The Soho name has been imitated by other entertainment and restaurant districts such as Soho, Hong Kong; Soho, Málaga; SOHO, Beijing; SoHo (South of Horton), London, Ontario, Canada; and Palermo Soho, Buenos Aires. SoHo, Manhattan, gets its name from its location SOuth of HOuston Street, but is also a reference to London’s Soho.

Long established as an entertainment district, for much of the 20th century Soho had a reputation as a base for the sex industry in addition to its night life and its location for the headquarters of leading film companies. Since the 1980s, the area has undergone considerable gentrification. It is now predominantly a fashionable district of upmarket restaurants and media offices, with only a small remnant of sex industry venues.

Soho is a small, multicultural area of central London; a home to industry, commerce, culture and entertainment, as well as a residential area for both rich and poor. It has clubs, including the former Chinawhite nightclub; public houses; bars; restaurants; a few sex shops scattered amongst them; and late-night coffee shops that give the streets an "open-all-night" feel at the weekends. Record shops cluster in the area around Berwick Street, with shops such as Phonica, Sister Ray and Reckless Records.